Sacl polymorphism defined by human T-cell receptor gamma (TCRG) variable gene V11

The V gamma locus of the human T cell receptor gamma gene. Repertoire polymorphism of the first variable gene segment subgroup

Southern blot analysis using a genomic probe of the human TCR-gamma chain first variable gene subgroup (V gamma I) was performed on DNA samples from both parents of 36 healthy Caucasian families. Two types of polymorphisms were found in these 72 unrelated DNA samples: three repertoire polymorphisms and two restriction fragment length polymorphisms (RFLP). In all cases, Mendelian inheritance of ...

Human T cell receptor V beta gene polymorphism

Southern blot hybridizations with human T cell receptor V beta gene probes were used to determine the sizes of the various V beta gene subfamilies. An analysis of DNA samples from 100 unrelated individuals identified a single individual who lacked one V beta gene segment. A second individual had an apparently different repertoire of V beta gene segments in one subfamily, as assayed by hybridiza...

T Cell Receptor g Gene Regulatory Sequences Prevent the Function of a Novel TCRg/pTa Pre–T Cell Receptor

and Cancer Research Laboratory ment, wherein cells destined to develop into ab T cells Division of Immunology must express a functional TCRb chain in order to effiUniversity of California at Berkeley ciently proceed to the CD252CD442 stage (Mombaerts Berkeley, California 94720 et al., 1992a; Shinkai et al., 1993; Dudley et al., 1994; †Basel Institute for Immunology Fehling et al., 1995). The su...

T cell gamma receptor.

A genetically determined insertion/deletion related polymorphism in human T cell receptor beta chain (TCRB) includes functional variable gene segments

Polymorphism in the human T cell receptor beta chain (TCRB) gene complex includes haplotypes with different numbers of TCRBV genes. An insertion/deletion related polymorphism (IDRP) in the human TCRBV region was found to involve TCRBV gene segments. Inserted TCRB haplotypes contain an additional 21.5 kb in which three TCRBV genes are encoded, members of the TCRBV7, TCRBV9, and TCRBV13 families....